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pentobarbital will reduce the extent or impact of tamoxifen by influencing hepatic enzyme CYP2C9/10 metabolism. Use Caution/Keep track of.pentobarbital will reduce the extent or impact of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with solid CYP3A4 inducers just isn't recommendedpentoba